This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DOCK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:112,161,873–112,162,630 | 44.1 kb | Distal (>10kb) Multiome | 400 | |
| chr7:112,198,216–112,198,364 | 8.0 kb | Proximal (<10kb) | 12 | |
| chr7:112,202,870–112,203,206 | 3.2 kb | Proximal (<10kb) | 160 | |
| chr7:112,204,339–112,204,483 | 1.9 kb | Proximal (<10kb) | 97 | |
| chr7:112,205,004–112,207,424 | 117 bp | At TSS Multiome | 937 | |
| chr7:112,249,400–112,250,828 | 43.8 kb | Distal (>10kb) Multiome | 130 | |
| chr7:112,449,726–112,451,867 | 244.0 kb | Distal (>10kb) Multiome | 1086 |
Genomic view of the DOCK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.