This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DNPH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNPH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNPH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,928,809–42,930,153 | 300.1 kb | Distal (>10kb) Multiome | 1111 | |
| chr6:42,960,347–42,961,147 | 268.8 kb | Distal (>10kb) Multiome | 597 | |
| chr6:42,978,475–42,979,742 | 250.3 kb | Distal (>10kb) Multiome | 914 | |
| chr6:42,983,832–42,985,046 | 245.0 kb | Distal (>10kb) Multiome | 737 | |
| chr6:43,013,264–43,014,790 | 215.4 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,020,970–43,021,878 | 208.0 kb | Distal (>10kb) Multiome | 766 | |
| chr6:43,053,156–43,054,116 | 175.6 kb | Distal (>10kb) Multiome | 1033 | |
| chr6:43,059,118–43,060,383 | 169.9 kb | Distal (>10kb) Multiome | 906 | |
| chr6:43,075,612–43,077,611 | 152.1 kb | Distal (>10kb) Multiome | 744 | |
| chr6:43,096,382–43,096,822 | 133.0 kb | Distal (>10kb) Multiome | 290 | |
| chr6:43,143,296–43,143,802 | 85.9 kb | Distal (>10kb) Multiome | 638 | |
| chr6:43,170,289–43,172,815 | 58.3 kb | Distal (>10kb) Multiome | 1025 | |
| chr6:43,173,720–43,174,910 | 54.9 kb | Distal (>10kb) Multiome | 765 | |
| chr6:43,181,838–43,182,555 | 47.3 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 35 bp | At TSS Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 17.7 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 38.2 kb | Distal (>10kb) Multiome | 772 | |
| chr6:43,285,054–43,285,508 | 55.9 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 79.4 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 140.2 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 198.2 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 225.2 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 248.1 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 277.4 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 280.9 kb | Distal (>10kb) Multiome HiCAR | 734 | |
| chr6:43,516,463–43,517,515 | 287.5 kb | Distal (>10kb) Multiome HiCAR | 904 |
Genomic view of the DNPH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.