DNASE2

deoxyribonuclease 2, lysosomal | DNL, DNL2

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

Member of: DE-7 Developmental clusters: GC2

Biological processes 12 terms

DNA catabolic process (GO:0006308)DNA endonuclease activity (GO:0004520)DNA metabolic process (GO:0006259)apoptotic DNA fragmentation (GO:0006309)apoptotic cell clearance (GO:0043277)deoxyribonuclease II activity (GO:0004531)deoxyribonuclease II activity (GO:0004531)deoxyribonuclease II activity (GO:0004531)extracellular exosome (GO:0070062)lysosome (GO:0005764)lysosome (GO:0005764)protein binding (GO:0005515)

Expression (TPM)

TFs regulating DNASE2 0 TFs

Transcription factors with Perturb-seq knockdown data for DNASE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNASE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DNASE2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNASE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,610,516–12,611,613	270.6 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	241.2 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	233.7 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	224.3 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	214.7 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	211.9 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	200.0 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	184.8 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	178.2 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	159.0 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	157.4 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	146.7 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	144.3 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	123.7 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	115.2 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	106.1 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	103.6 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	98.7 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	91.4 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	90.0 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	87.8 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	79.5 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	74.9 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	55.7 kb	Distal (>10kb) Multiome	436
chr19:12,832,484–12,833,101	48.8 kb	Distal (>10kb) Multiome	970
chr19:12,833,638–12,834,477	47.5 kb	Distal (>10kb) Multiome	310
chr19:12,838,114–12,838,869	43.0 kb	Distal (>10kb) Multiome	377
chr19:12,840,071–12,841,485	40.6 kb	Distal (>10kb) Multiome	391
chr19:12,847,633–12,848,090	33.7 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	13.8 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	8.1 kb	Proximal (<10kb) Multiome	263
chr19:12,880,834–12,881,875	20 bp	At TSS Multiome	656
chr19:12,884,836–12,886,381	3.9 kb	Proximal (<10kb) Multiome	717
chr19:12,890,614–12,891,603	9.5 kb	Proximal (<10kb) Multiome	841
chr19:12,913,054–12,913,584	31.9 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	37.9 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	52.3 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	57.0 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	64.5 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	75.8 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	84.0 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	102.2 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	170.4 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	180.0 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	188.4 kb	Distal (>10kb) Multiome	334
chr19:13,093,620–13,094,260	212.4 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	214.0 kb	Distal (>10kb) Multiome	501
chr19:13,102,495–13,103,074	221.4 kb	Distal (>10kb) Multiome	606
chr19:13,116,411–13,117,080	235.3 kb	Distal (>10kb) Multiome	812
chr19:13,117,979–13,119,416	236.8 kb	Distal (>10kb) Multiome	699
chr19:13,149,468–13,156,577	268.8 kb	Distal (>10kb) Multiome	1333
chr19:13,162,579–13,165,523	283.3 kb	Distal (>10kb) Multiome	1112
chr19:13,167,359–13,168,023	286.2 kb	Distal (>10kb) Multiome	764

Genome Browser

Genomic view of the DNASE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.