This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for DNAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,457,486–73,459,145 | 186.3 kb | Distal (>10kb) Multiome | 720 | |
| chr14:73,490,604–73,491,982 | 154.0 kb | Distal (>10kb) Multiome | 866 | |
| chr14:73,569,145–73,570,199 | 75.6 kb | Distal (>10kb) Multiome | 680 | |
| chr14:73,591,810–73,592,493 | 52.9 kb | Distal (>10kb) Multiome | 259 | |
| chr14:73,612,266–73,613,237 | 32.4 kb | Distal (>10kb) Multiome | 521 | |
| chr14:73,633,521–73,634,788 | 11.4 kb | Distal (>10kb) Multiome | 541 | |
| chr14:73,644,535–73,645,291 | 107 bp | At TSS Multiome | 667 | |
| chr14:73,713,545–73,714,769 | 69.3 kb | Distal (>10kb) Multiome | 759 | |
| chr14:73,718,770–73,719,334 | 74.1 kb | Distal (>10kb) Multiome | 138 | |
| chr14:73,759,247–73,760,633 | 115.3 kb | Distal (>10kb) Multiome | 912 | |
| chr14:73,771,644–73,772,269 | 127.0 kb | Distal (>10kb) Multiome | 846 | |
| chr14:73,785,281–73,785,818 | 140.5 kb | Distal (>10kb) Multiome | 458 | |
| chr14:73,786,685–73,787,517 | 142.2 kb | Distal (>10kb) Multiome | 497 | |
| chr14:73,851,491–73,852,843 | 206.9 kb | Distal (>10kb) Multiome | 842 | |
| chr14:73,886,331–73,887,426 | 241.8 kb | Distal (>10kb) Multiome | 963 |
Genomic view of the DNAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.