This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DNAJB6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:157,138,376–157,139,695 | 198.2 kb | Distal (>10kb) Multiome | 863 | |
| chr7:157,273,400–157,274,009 | 63.3 kb | Distal (>10kb) Multiome | 578 | |
| chr7:157,279,203–157,279,779 | 57.5 kb | Distal (>10kb) Multiome | 291 | |
| chr7:157,310,335–157,311,049 | 26.4 kb | Distal (>10kb) Multiome | 312 | |
| chr7:157,336,012–157,338,044 | 66 bp | At TSS Multiome | 778 | |
| chr7:157,338,590–157,338,932 | 1.6 kb | Proximal (<10kb) | 219 | |
| chr7:157,339,092–157,339,451 | 2.1 kb | Proximal (<10kb) | 113 | |
| chr7:157,339,970–157,340,106 | 3.0 kb | Proximal (<10kb) | 126 | |
| chr7:157,340,229–157,340,386 | 3.2 kb | Proximal (<10kb) | 220 |
Genomic view of the DNAJB6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.