The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for DNAJB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:77,681,742–77,684,058 | 295.8 kb | Distal (>10kb) Multiome | 1050 | |
| chr1:77,686,763–77,688,131 | 291.5 kb | Distal (>10kb) Multiome | 208 | |
| chr1:77,758,895–77,760,199 | 219.4 kb | Distal (>10kb) Multiome | 856 | |
| chr1:77,779,465–77,780,294 | 199.5 kb | Distal (>10kb) Multiome | 779 | |
| chr1:77,888,069–77,889,521 | 90.5 kb | Distal (>10kb) Multiome | 648 | |
| chr1:77,906,727–77,907,344 | 72.2 kb | Distal (>10kb) Multiome | 128 | |
| chr1:77,976,530–77,976,964 | 2.3 kb | Proximal (<10kb) | 75 | |
| chr1:77,978,065–77,980,001 | 29 bp | At TSS Multiome | 993 | |
| chr1:77,983,355–77,983,855 | 4.1 kb | Proximal (<10kb) | 37 | |
| chr1:78,045,313–78,046,896 | 67.0 kb | Distal (>10kb) Multiome | 583 | |
| chr1:78,200,021–78,201,015 | 221.1 kb | Distal (>10kb) Multiome | 129 | |
| chr1:78,214,003–78,214,778 | 235.2 kb | Distal (>10kb) Multiome | 12 | |
| chr1:78,226,716–78,228,073 | 248.1 kb | Distal (>10kb) Multiome | 201 | |
| chr1:78,236,703–78,237,945 | 258.4 kb | Distal (>10kb) Multiome | 336 |
Genomic view of the DNAJB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.