This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for DNAJB11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJB11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJB11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:186,361,726–186,362,566 | 208.5 kb | Distal (>10kb) Multiome | 278 | |
| chr3:186,382,314–186,383,518 | 188.0 kb | Distal (>10kb) Multiome | 146 | |
| chr3:186,413,600–186,414,426 | 156.7 kb | Distal (>10kb) Multiome | 179 | |
| chr3:186,469,999–186,470,758 | 100.4 kb | Distal (>10kb) Multiome | 31 | |
| chr3:186,566,830–186,567,930 | 3.4 kb | Proximal (<10kb) Multiome | 850 | |
| chr3:186,570,047–186,571,165 | 162 bp | At TSS Multiome | 735 | |
| chr3:186,653,868–186,654,549 | 83.5 kb | Distal (>10kb) Multiome | 163 | |
| chr3:186,772,225–186,772,685 | 201.8 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr3:186,772,788–186,773,308 | 202.3 kb | Distal (>10kb) Multiome HiCAR | 241 | |
| chr3:186,775,941–186,776,679 | 205.5 kb | Distal (>10kb) Multiome HiCAR | 161 | |
| chr3:186,782,866–186,784,510 | 213.5 kb | Distal (>10kb) Multiome HiCAR | 1121 | |
| chr3:186,806,142–186,807,252 | 235.9 kb | Distal (>10kb) Multiome HiCAR | 877 | |
| chr3:186,824,344–186,826,061 | 254.9 kb | Distal (>10kb) Multiome | 328 | |
| chr3:186,827,252–186,828,058 | 256.9 kb | Distal (>10kb) Multiome | 539 |
Genomic view of the DNAJB11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.