Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNAI4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAI4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAI4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:65,147,108–65,150,062 | 1775.6 kb | Distal (>10kb) Multiome HiCAR | 912 | |
| chr1:66,751,604–66,753,218 | 172.4 kb | Distal (>10kb) Multiome | 318 | |
| chr1:66,916,371–66,916,586 | 8.3 kb | Proximal (<10kb) | 189 | |
| chr1:66,923,845–66,926,268 | 320 bp | At TSS Multiome | 945 | |
| chr1:66,929,624–66,931,089 | 5.4 kb | Proximal (<10kb) Multiome | 922 | |
| chr1:67,053,062–67,054,800 | 128.8 kb | Distal (>10kb) Multiome | 993 |
Genomic view of the DNAI4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.