This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for DNAH11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAH11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAH11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:21,426,323–21,428,778 | 114.9 kb | Distal (>10kb) Multiome | 900 | |
| chr7:21,542,670–21,544,079 | 66 bp | At TSS Multiome | 383 | |
| chr7:21,551,184–21,551,448 | 8.1 kb | Proximal (<10kb) | 102 | |
| chr7:21,642,273–21,643,074 | 99.6 kb | Distal (>10kb) Multiome | 97 | |
| chr7:21,771,740–21,772,441 | 229.1 kb | Distal (>10kb) Multiome | 259 |
Genomic view of the DNAH11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.