This gene encodes an uncharacterized protein with a C-terminal coiled-coil region. The gene is located on chromosome 20p13 in a 1.8 Mb region linked to a spinocerebellar ataxia phenotype, but this gene does not appear to be a disease candidate. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for DNAAF9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAAF9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAAF9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:3,159,566–3,160,153 | 247.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr20:3,168,012–3,168,864 | 239.3 kb | Distal (>10kb) Multiome | 598 | |
| chr20:3,172,885–3,174,573 | 234.1 kb | Distal (>10kb) Multiome | 1012 | |
| chr20:3,203,485–3,204,801 | 203.1 kb | Distal (>10kb) Multiome | 952 | |
| chr20:3,218,394–3,218,992 | 189.0 kb | Distal (>10kb) Multiome | 638 | |
| chr20:3,238,062–3,240,422 | 168.2 kb | Distal (>10kb) Multiome | 714 | |
| chr20:3,407,081–3,408,415 | 106 bp | At TSS Multiome | 825 | |
| chr20:3,408,525–3,409,169 | 1.3 kb | Proximal (<10kb) Multiome | 453 | |
| chr20:3,470,330–3,471,668 | 63.3 kb | Distal (>10kb) Multiome | 975 | |
| chr20:3,672,530–3,673,055 | 265.0 kb | Distal (>10kb) Multiome | 158 | |
| chr20:3,681,778–3,682,557 | 274.5 kb | Distal (>10kb) Multiome | 170 |
Genomic view of the DNAAF9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.