This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for DNA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,208,472–68,208,961 | 263.3 kb | Distal (>10kb) Multiome | 254 | |
| chr10:68,231,028–68,232,253 | 240.5 kb | Distal (>10kb) Multiome | 654 | |
| chr10:68,271,165–68,272,025 | 200.4 kb | Distal (>10kb) Multiome | 177 | |
| chr10:68,331,343–68,333,064 | 139.0 kb | Distal (>10kb) Multiome | 1174 | |
| chr10:68,406,245–68,407,662 | 64.7 kb | Distal (>10kb) Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 41 bp | At TSS Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 55.6 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 88.4 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 128.5 kb | Distal (>10kb) Multiome | 755 | |
| chr10:68,720,659–68,721,908 | 249.2 kb | Distal (>10kb) Multiome | 939 |
Genomic view of the DNA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.