Transcription factors with Perturb-seq knockdown data for DLEU7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLEU7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLEU7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:50,080,906–50,083,082 | 761.6 kb | Distal (>10kb) Multiome HiCAR | 885 | |
| chr13:50,123,622–50,126,557 | 719.3 kb | Distal (>10kb) Multiome HiCAR | 1075 | |
| chr13:50,676,407–50,677,028 | 167.0 kb | Distal (>10kb) Multiome | 203 | |
| chr13:50,779,449–50,780,341 | 63.8 kb | Distal (>10kb) Multiome | 141 | |
| chr13:50,842,911–50,844,242 | 12 bp | At TSS Multiome | 210 | |
| chr13:50,909,544–50,910,786 | 66.2 kb | Distal (>10kb) Multiome | 827 | |
| chr13:51,101,590–51,102,215 | 258.1 kb | Distal (>10kb) Multiome | 123 | |
| chr13:51,122,652–51,123,430 | 279.4 kb | Distal (>10kb) Multiome | 298 | |
| chr13:51,125,567–51,126,048 | 282.1 kb | Distal (>10kb) Multiome | 224 |
Genomic view of the DLEU7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.