This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DKK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DKK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DKK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,139,747–42,140,990 | 236.6 kb | Distal (>10kb) Multiome | 779 | |
| chr8:42,151,983–42,153,808 | 224.3 kb | Distal (>10kb) Multiome HiCAR | 975 | |
| chr8:42,270,718–42,271,870 | 105.9 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 38.8 kb | Distal (>10kb) Multiome | 710 | |
| chr8:42,372,464–42,372,798 | 4.4 kb | Proximal (<10kb) | 7 | |
| chr8:42,374,387–42,374,628 | 2.6 kb | Proximal (<10kb) | 11 | |
| chr8:42,376,919–42,377,769 | 122 bp | At TSS Multiome | 159 | |
| chr8:42,385,535–42,385,724 | 8.3 kb | Proximal (<10kb) | 305 | |
| chr8:42,391,151–42,392,597 | 14.5 kb | Distal (>10kb) Multiome | 831 | |
| chr8:42,541,069–42,542,355 | 164.5 kb | Distal (>10kb) Multiome | 767 | |
| chr8:42,571,247–42,571,811 | 194.3 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the DKK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.