The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for DIXDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIXDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIXDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:110,295,762–110,297,308 | 1640.6 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr11:111,765,276–111,766,937 | 170.9 kb | Distal (>10kb) Multiome | 726 | |
| chr11:111,784,858–111,785,661 | 152.1 kb | Distal (>10kb) Multiome | 164 | |
| chr11:111,870,839–111,871,692 | 66.1 kb | Distal (>10kb) Multiome HiCAR | 781 | |
| chr11:111,878,459–111,879,798 | 58.2 kb | Distal (>10kb) Multiome HiCAR | 970 | |
| chr11:111,918,534–111,919,259 | 18.4 kb | Distal (>10kb) Multiome HiCAR | 468 | |
| chr11:111,926,372–111,927,689 | 10.2 kb | Distal (>10kb) Multiome | 767 | |
| chr11:111,931,856–111,932,121 | 5.2 kb | Proximal (<10kb) | 228 | |
| chr11:111,936,752–111,938,016 | 81 bp | At TSS Multiome | 671 | |
| chr11:111,938,717–111,938,992 | 1.4 kb | Proximal (<10kb) | 188 | |
| chr11:111,960,703–111,961,374 | 23.7 kb | Distal (>10kb) Multiome | 192 | |
| chr11:111,976,357–111,978,029 | 39.8 kb | Distal (>10kb) Multiome HiCAR | 293 | |
| chr11:111,978,348–111,978,695 | 1.0 kb | Proximal (<10kb) | 178 | |
| chr11:111,981,895–111,982,316 | 4.6 kb | Proximal (<10kb) | 211 | |
| chr11:111,982,641–111,983,482 | 46.0 kb | Distal (>10kb) Multiome HiCAR | 290 | |
| chr11:112,024,495–112,025,893 | 87.8 kb | Distal (>10kb) Multiome | 1024 | |
| chr11:112,073,749–112,074,754 | 136.8 kb | Distal (>10kb) Multiome | 828 | |
| chr11:112,086,268–112,087,320 | 149.4 kb | Distal (>10kb) Multiome | 883 | |
| chr11:112,225,928–112,226,959 | 289.1 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the DIXDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.