Enables 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DIS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:72,726,793–72,728,423 | 54.2 kb | Distal (>10kb) Multiome | 908 | |
| chr13:72,781,287–72,782,590 | 95 bp | At TSS Multiome | 793 | |
| chr13:73,039,002–73,040,203 | 257.9 kb | Distal (>10kb) Multiome | 182 | |
| chr13:73,058,366–73,060,121 | 277.0 kb | Distal (>10kb) Multiome | 776 | |
| chr13:73,765,465–73,766,384 | 984.1 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr13:73,767,698–73,768,912 | 986.3 kb | Distal (>10kb) Multiome HiCAR | 165 |
Genomic view of the DIS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.