The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for DIMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:62,138,351–62,139,212 | 265.1 kb | Distal (>10kb) Multiome | 146 | |
| chr5:62,218,824–62,219,304 | 184.9 kb | Distal (>10kb) Multiome | 27 | |
| chr5:62,305,482–62,307,335 | 97.8 kb | Distal (>10kb) Multiome | 1045 | |
| chr5:62,403,358–62,404,699 | 50 bp | At TSS Multiome | 1008 | |
| chr5:62,411,784–62,413,278 | 8.8 kb | Proximal (<10kb) Multiome | 867 |
Genomic view of the DIMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.