This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for DHX40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHX40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHX40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:58,513,911–58,515,157 | 1051.0 kb | Distal (>10kb) Multiome HiCAR | 585 | |
| chr17:58,517,239–58,519,377 | 1047.6 kb | Distal (>10kb) Multiome HiCAR | 1140 | |
| chr17:59,289,802–59,290,844 | 275.1 kb | Distal (>10kb) Multiome HiCAR | 553 | |
| chr17:59,297,022–59,297,671 | 268.3 kb | Distal (>10kb) Multiome HiCAR | 298 | |
| chr17:59,329,140–59,330,952 | 235.9 kb | Distal (>10kb) Multiome | 623 | |
| chr17:59,331,110–59,332,553 | 234.0 kb | Distal (>10kb) Multiome | 723 | |
| chr17:59,365,177–59,365,986 | 200.0 kb | Distal (>10kb) Multiome | 397 | |
| chr17:59,366,194–59,368,736 | 198.7 kb | Distal (>10kb) Multiome | 784 | |
| chr17:59,370,634–59,371,353 | 194.7 kb | Distal (>10kb) Multiome | 95 | |
| chr17:59,418,775–59,419,543 | 146.5 kb | Distal (>10kb) Multiome | 216 | |
| chr17:59,423,282–59,424,320 | 141.7 kb | Distal (>10kb) Multiome | 316 | |
| chr17:59,565,384–59,566,262 | 25 bp | At TSS Multiome | 1120 | |
| chr17:59,619,053–59,620,313 | 54.0 kb | Distal (>10kb) Multiome | 1183 | |
| chr17:59,707,078–59,708,143 | 142.0 kb | Distal (>10kb) Multiome | 963 | |
| chr17:59,837,406–59,838,036 | 272.1 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the DHX40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.