Predicted to enable acylglycerone-phosphate reductase (NADP+) activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for DHRS7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:20,843,455–20,844,334 | 283.0 kb | Distal (>10kb) Multiome | 77 | |
| chr17:20,868,077–20,868,766 | 258.5 kb | Distal (>10kb) Multiome | 123 | |
| chr17:20,908,196–20,908,861 | 218.3 kb | Distal (>10kb) Multiome | 516 | |
| chr17:20,992,594–20,993,594 | 133.8 kb | Distal (>10kb) Multiome | 237 | |
| chr17:21,041,818–21,044,206 | 83.7 kb | Distal (>10kb) Multiome | 1019 | |
| chr17:21,098,970–21,099,982 | 27.6 kb | Distal (>10kb) Multiome | 514 | |
| chr17:21,106,347–21,107,024 | 20.3 kb | Distal (>10kb) Multiome | 32 | |
| chr17:21,108,710–21,109,234 | 18.1 kb | Distal (>10kb) Multiome | 13 | |
| chr17:21,119,706–21,119,946 | 7.0 kb | Proximal (<10kb) | 236 | |
| chr17:21,126,572–21,127,535 | 35 bp | At TSS Multiome | 707 | |
| chr17:21,213,670–21,215,538 | 87.4 kb | Distal (>10kb) Multiome | 849 | |
| chr17:21,252,548–21,253,969 | 126.4 kb | Distal (>10kb) Multiome | 558 | |
| chr17:21,275,381–21,276,434 | 149.0 kb | Distal (>10kb) Multiome | 671 | |
| chr17:21,280,014–21,280,480 | 153.2 kb | Distal (>10kb) Multiome | 435 | |
| chr17:21,283,767–21,285,795 | 157.6 kb | Distal (>10kb) Multiome | 672 | |
| chr17:21,322,850–21,323,584 | 196.2 kb | Distal (>10kb) Multiome | 172 | |
| chr17:21,376,013–21,377,629 | 249.6 kb | Distal (>10kb) Multiome | 253 |
Genomic view of the DHRS7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.