This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for DHRS4L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS4L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS4L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,910,478–23,911,853 | 78.0 kb | Distal (>10kb) Multiome | 310 | |
| chr14:23,953,479–23,954,293 | 35.0 kb | Distal (>10kb) Multiome | 897 | |
| chr14:23,988,469–23,989,172 | 3 bp | At TSS Multiome | 439 | |
| chr14:24,036,218–24,036,993 | 47.7 kb | Distal (>10kb) Multiome HiCAR | 627 | |
| chr14:24,051,239–24,052,875 | 63.1 kb | Distal (>10kb) Multiome HiCAR | 821 | |
| chr14:24,080,914–24,082,038 | 92.7 kb | Distal (>10kb) Multiome HiCAR | 706 | |
| chr14:24,093,491–24,095,115 | 105.4 kb | Distal (>10kb) Multiome HiCAR | 990 | |
| chr14:24,113,681–24,115,917 | 126.1 kb | Distal (>10kb) Multiome | 1166 | |
| chr14:24,135,549–24,136,884 | 147.3 kb | Distal (>10kb) Multiome | 778 | |
| chr14:24,140,526–24,142,331 | 152.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr14:24,146,204–24,148,108 | 158.0 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 172.4 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 183.1 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 200.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 206.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 224.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 227.2 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 243.7 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 253.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 282.6 kb | Distal (>10kb) Multiome | 1089 |
Genomic view of the DHRS4L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.