Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DGLUCY. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGLUCY upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGLUCY, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:90,816,013–90,817,051 | 297.6 kb | Distal (>10kb) Multiome | 233 | |
| chr14:90,827,894–90,828,472 | 285.8 kb | Distal (>10kb) Multiome | 550 | |
| chr14:91,059,736–91,061,424 | 53.2 kb | Distal (>10kb) Multiome | 848 | |
| chr14:91,113,925–91,114,783 | 162 bp | At TSS Multiome | 710 | |
| chr14:91,252,762–91,254,136 | 139.3 kb | Distal (>10kb) Multiome | 429 | |
| chr14:91,264,238–91,265,162 | 150.6 kb | Distal (>10kb) Multiome | 276 | |
| chr14:91,302,942–91,304,213 | 189.4 kb | Distal (>10kb) Multiome | 215 | |
| chr14:91,413,560–91,414,125 | 299.7 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the DGLUCY locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.