This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DGKD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGKD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGKD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:233,129,373–233,130,063 | 224.8 kb | Distal (>10kb) Multiome | 111 | |
| chr2:233,139,260–233,139,740 | 215.1 kb | Distal (>10kb) Multiome | 98 | |
| chr2:233,251,235–233,252,102 | 102.9 kb | Distal (>10kb) Multiome | 955 | |
| chr2:233,353,271–233,354,945 | 163 bp | At TSS Multiome | 679 | |
| chr2:233,408,408–233,410,885 | 54.5 kb | Distal (>10kb) Multiome | 338 | |
| chr2:233,566,080–233,566,971 | 212.2 kb | Distal (>10kb) Multiome | 941 |
Genomic view of the DGKD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.