This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for DGAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:75,524,766–75,526,517 | 242.7 kb | Distal (>10kb) Multiome | 663 | |
| chr11:75,547,627–75,548,081 | 220.9 kb | Distal (>10kb) Multiome | 241 | |
| chr11:75,559,107–75,559,968 | 209.2 kb | Distal (>10kb) Multiome | 262 | |
| chr11:75,561,674–75,564,448 | 206.5 kb | Distal (>10kb) Multiome | 813 | |
| chr11:75,582,925–75,584,268 | 184.8 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr11:75,667,242–75,669,059 | 101.1 kb | Distal (>10kb) Multiome | 328 | |
| chr11:75,768,053–75,769,178 | 75 bp | At TSS Multiome | 885 | |
| chr11:75,775,108–75,775,370 | 6.4 kb | Proximal (<10kb) | 22 | |
| chr11:75,780,954–75,781,467 | 12.4 kb | Distal (>10kb) Multiome | 37 | |
| chr11:75,814,230–75,815,903 | 46.3 kb | Distal (>10kb) Multiome | 814 | |
| chr11:75,979,208–75,979,827 | 210.8 kb | Distal (>10kb) Multiome | 62 |
Genomic view of the DGAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.