Enables ubiquitin protein ligase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DET1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DET1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DET1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,246,462–88,247,390 | 299.7 kb | Distal (>10kb) Multiome | 349 | |
| chr15:88,256,583–88,257,904 | 289.8 kb | Distal (>10kb) Multiome | 199 | |
| chr15:88,258,031–88,258,757 | 288.3 kb | Distal (>10kb) Multiome | 208 | |
| chr15:88,388,191–88,389,364 | 157.8 kb | Distal (>10kb) Multiome | 280 | |
| chr15:88,467,068–88,468,013 | 79.2 kb | Distal (>10kb) Multiome | 857 | |
| chr15:88,537,723–88,539,073 | 8.0 kb | Proximal (<10kb) Multiome | 141 | |
| chr15:88,543,063–88,543,330 | 3.3 kb | Proximal (<10kb) | 55 | |
| chr15:88,545,733–88,547,888 | 162 bp | At TSS Multiome | 818 | |
| chr15:88,548,047–88,548,282 | 1.4 kb | Proximal (<10kb) | 29 | |
| chr15:88,571,230–88,572,235 | 25.0 kb | Distal (>10kb) Multiome | 149 | |
| chr15:88,604,930–88,605,917 | 59.0 kb | Distal (>10kb) Multiome | 530 | |
| chr15:88,610,494–88,611,216 | 64.2 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr15:88,612,843–88,613,762 | 66.7 kb | Distal (>10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 68.1 kb | Distal (>10kb) Multiome HiCAR | 414 | |
| chr15:88,620,659–88,621,775 | 74.6 kb | Distal (>10kb) Multiome | 829 | |
| chr15:88,638,306–88,639,588 | 92.3 kb | Distal (>10kb) Multiome | 1000 | |
| chr15:88,802,773–88,804,052 | 256.8 kb | Distal (>10kb) Multiome | 209 |
Genomic view of the DET1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.