Enables deoxyribose-phosphate aldolase activity. Involved in deoxyribonucleoside catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DERA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DERA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DERA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,768,991–14,772,177 | 1141.4 kb | Distal (>10kb) Multiome HiCAR | 1151 | |
| chr12:14,773,514–14,775,433 | 1137.0 kb | Distal (>10kb) Multiome HiCAR | 550 | |
| chr12:15,637,045–15,638,446 | 273.5 kb | Distal (>10kb) Multiome | 168 | |
| chr12:15,788,278–15,790,322 | 121.9 kb | Distal (>10kb) Multiome | 987 | |
| chr12:15,881,783–15,883,039 | 29.0 kb | Distal (>10kb) Multiome | 910 | |
| chr12:15,910,800–15,911,739 | 1 bp | At TSS Multiome | 788 | |
| chr12:15,911,842–15,912,820 | 514 bp | At TSS | 225 | |
| chr12:15,920,251–15,920,446 | 8.9 kb | Proximal (<10kb) | 9 | |
| chr12:16,112,192–16,113,482 | 201.6 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the DERA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.