Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DEPTOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEPTOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEPTOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:119,638,540–119,639,410 | 234.8 kb | Distal (>10kb) Multiome | 275 | |
| chr8:119,672,030–119,673,835 | 200.4 kb | Distal (>10kb) Multiome | 397 | |
| chr8:119,832,338–119,833,429 | 40.9 kb | Distal (>10kb) Multiome | 811 | |
| chr8:119,855,284–119,857,254 | 17.8 kb | Distal (>10kb) Multiome | 941 | |
| chr8:119,866,843–119,867,433 | 6.3 kb | Proximal (<10kb) | 302 | |
| chr8:119,873,210–119,874,965 | 7 bp | At TSS Multiome | 871 | |
| chr8:120,047,941–120,048,921 | 174.6 kb | Distal (>10kb) Multiome | 198 | |
| chr8:120,123,318–120,126,661 | 250.0 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the DEPTOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.