Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DEPDC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEPDC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEPDC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:99,983,831–99,985,388 | 282.2 kb | Distal (>10kb) Multiome | 468 | |
| chr12:100,064,385–100,065,093 | 202.4 kb | Distal (>10kb) Multiome | 21 | |
| chr12:100,141,965–100,143,502 | 124.2 kb | Distal (>10kb) Multiome | 848 | |
| chr12:100,154,424–100,155,274 | 112.2 kb | Distal (>10kb) Multiome | 267 | |
| chr12:100,163,261–100,164,604 | 103.0 kb | Distal (>10kb) Multiome | 445 | |
| chr12:100,199,080–100,201,296 | 66.3 kb | Distal (>10kb) Multiome | 955 | |
| chr12:100,266,312–100,267,966 | 2 bp | At TSS Multiome | 833 | |
| chr12:100,404,822–100,405,325 | 137.9 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the DEPDC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.