Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of triglyceride transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,323,558–31,326,665 | 266.7 kb | Distal (>10kb) Multiome | 943 | |
| chr12:31,346,903–31,347,737 | 243.7 kb | Distal (>10kb) Multiome | 105 | |
| chr12:31,362,120–31,363,072 | 228.4 kb | Distal (>10kb) Multiome | 485 | |
| chr12:31,368,619–31,369,388 | 221.9 kb | Distal (>10kb) Multiome | 173 | |
| chr12:31,370,717–31,371,181 | 219.9 kb | Distal (>10kb) Multiome | 293 | |
| chr12:31,589,796–31,591,586 | 122 bp | At TSS Multiome | 875 | |
| chr12:31,659,057–31,659,786 | 68.3 kb | Distal (>10kb) Multiome | 737 | |
| chr12:31,728,407–31,729,774 | 138.1 kb | Distal (>10kb) Multiome | 938 | |
| chr12:31,732,968–31,733,511 | 142.3 kb | Distal (>10kb) Multiome | 430 | |
| chr12:31,749,119–31,749,785 | 158.5 kb | Distal (>10kb) Multiome | 885 |
Genomic view of the DENND5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.