Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Rab protein signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,658,331–153,659,230 | 288.0 kb | Distal (>10kb) Multiome | 746 | |
| chr1:153,670,709–153,671,992 | 275.6 kb | Distal (>10kb) Multiome | 884 | |
| chr1:153,697,776–153,698,654 | 248.4 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 218.8 kb | Distal (>10kb) Multiome | 702 | |
| chr1:153,736,782–153,737,426 | 209.6 kb | Distal (>10kb) Multiome | 10 | |
| chr1:153,745,487–153,745,959 | 201.1 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 171.5 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 163.0 kb | Distal (>10kb) Multiome | 794 | |
| chr1:153,922,213–153,923,779 | 23.7 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 31 bp | At TSS Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 11.9 kb | Distal (>10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 16.9 kb | Distal (>10kb) Multiome | 798 | |
| chr1:153,967,147–153,968,324 | 20.9 kb | Distal (>10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 30.9 kb | Distal (>10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 39.7 kb | Distal (>10kb) Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 44.0 kb | Distal (>10kb) Multiome | 950 | |
| chr1:154,182,339–154,183,774 | 236.6 kb | Distal (>10kb) Multiome | 934 | |
| chr1:154,220,079–154,221,864 | 274.0 kb | Distal (>10kb) Multiome | 1071 |
Genomic view of the DENND4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.