Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Located in late endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DENND10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DENND10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DENND10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,022,769–119,023,594 | 80.9 kb | Distal (>10kb) Multiome | 196 | |
| chr10:119,028,784–119,030,985 | 74.6 kb | Distal (>10kb) Multiome | 776 | |
| chr10:119,080,039–119,081,458 | 23.2 kb | Distal (>10kb) Multiome | 953 | |
| chr10:119,092,145–119,092,653 | 11.6 kb | Distal (>10kb) Multiome | 103 | |
| chr10:119,103,400–119,104,998 | 5 bp | At TSS Multiome | 607 | |
| chr10:119,140,467–119,141,205 | 36.9 kb | Distal (>10kb) Multiome | 164 | |
| chr10:119,165,095–119,166,223 | 61.6 kb | Distal (>10kb) Multiome | 815 | |
| chr10:119,178,426–119,179,231 | 74.7 kb | Distal (>10kb) Multiome | 801 | |
| chr10:119,206,342–119,208,274 | 103.3 kb | Distal (>10kb) Multiome | 780 |
Genomic view of the DENND10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.