Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for DDR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,614,393–30,615,939 | 265.8 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 263.5 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 254.1 kb | Distal (>10kb) Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 233.7 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 208.0 kb | Distal (>10kb) Multiome | 812 | |
| chr6:30,679,032–30,679,479 | 201.8 kb | Distal (>10kb) Multiome | 603 | |
| chr6:30,686,268–30,688,032 | 193.7 kb | Distal (>10kb) Multiome | 801 | |
| chr6:30,690,445–30,691,240 | 190.0 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,716,986–30,717,874 | 163.5 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 160.8 kb | Distal (>10kb) Multiome | 724 | |
| chr6:30,721,307–30,722,103 | 159.5 kb | Distal (>10kb) Multiome | 872 | |
| chr6:30,725,731–30,726,564 | 154.8 kb | Distal (>10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 138.2 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 116.6 kb | Distal (>10kb) Multiome | 850 | |
| chr6:30,877,746–30,878,033 | 3.0 kb | Proximal (<10kb) | 593 | |
| chr6:30,880,638–30,881,295 | 22 bp | At TSS Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 1.9 kb | Proximal (<10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 3.4 kb | Proximal (<10kb) Multiome | 538 | |
| chr6:30,886,419–30,886,709 | 5.4 kb | Proximal (<10kb) | 310 | |
| chr6:30,907,770–30,908,494 | 27.1 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 33.2 kb | Distal (>10kb) Multiome | 944 | |
| chr6:30,942,475–30,943,087 | 61.8 kb | Distal (>10kb) Multiome | 300 | |
| chr6:30,955,192–30,955,975 | 74.7 kb | Distal (>10kb) Multiome | 524 | |
| chr6:31,157,467–31,159,255 | 277.4 kb | Distal (>10kb) Multiome | 740 | |
| chr6:31,171,796–31,173,419 | 291.1 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the DDR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.