Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DDIAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDIAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDIAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,695,267–82,696,305 | 205.9 kb | Distal (>10kb) Multiome | 385 | |
| chr11:82,732,363–82,734,437 | 167.9 kb | Distal (>10kb) Multiome HiCAR | 442 | |
| chr11:82,750,605–82,751,145 | 150.8 kb | Distal (>10kb) Multiome | 218 | |
| chr11:82,775,808–82,776,868 | 125.6 kb | Distal (>10kb) Multiome | 252 | |
| chr11:82,899,722–82,902,187 | 59 bp | At TSS Multiome | 1001 | |
| chr11:82,908,868–82,909,477 | 7.1 kb | Proximal (<10kb) | 35 | |
| chr11:82,970,431–82,971,628 | 69.1 kb | Distal (>10kb) Multiome | 188 | |
| chr11:83,034,012–83,034,897 | 132.8 kb | Distal (>10kb) Multiome | 343 | |
| chr11:83,071,319–83,072,558 | 170.2 kb | Distal (>10kb) Multiome HiCAR | 943 | |
| chr11:83,144,373–83,145,287 | 243.1 kb | Distal (>10kb) Multiome HiCAR | 76 | |
| chr11:83,156,155–83,158,430 | 255.1 kb | Distal (>10kb) Multiome HiCAR | 1001 | |
| chr11:83,193,357–83,194,770 | 292.0 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr11:83,241,143–83,241,871 | 339.8 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr11:83,724,266–83,725,551 | 823.3 kb | Distal (>10kb) Multiome HiCAR | 319 |
Genomic view of the DDIAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.