Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCUN1D4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCUN1D4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCUN1D4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:51,842,079–51,845,206 | 1.6 kb | Proximal (<10kb) Multiome | 896 | |
| chr4:51,884,682–51,884,965 | at TSS | At TSS | 11 | |
| chr4:51,885,435–51,885,677 | 525 bp | At TSS | 57 | |
| chr4:51,957,662–51,959,004 | 115.4 kb | Distal (>10kb) Multiome | 174 | |
| chr4:52,037,751–52,038,942 | 195.1 kb | Distal (>10kb) Multiome HiCAR | 454 | |
| chr4:52,051,228–52,052,688 | 208.8 kb | Distal (>10kb) Multiome HiCAR | 636 |
Genomic view of the DCUN1D4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.