This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for DCPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:126,061,736–126,063,712 | 241.0 kb | Distal (>10kb) Multiome | 802 | |
| chr11:126,082,403–126,083,132 | 221.3 kb | Distal (>10kb) Multiome | 134 | |
| chr11:126,104,267–126,104,892 | 199.5 kb | Distal (>10kb) Multiome | 192 | |
| chr11:126,159,698–126,160,582 | 144.0 kb | Distal (>10kb) Multiome | 281 | |
| chr11:126,210,869–126,212,282 | 92.4 kb | Distal (>10kb) Multiome | 846 | |
| chr11:126,268,478–126,269,613 | 35.0 kb | Distal (>10kb) Multiome | 828 | |
| chr11:126,282,310–126,283,787 | 21.0 kb | Distal (>10kb) Multiome | 754 | |
| chr11:126,303,694–126,304,639 | 22 bp | At TSS Multiome | 979 | |
| chr11:126,310,571–126,310,929 | 6.5 kb | Proximal (<10kb) | 285 | |
| chr11:126,345,823–126,346,956 | 42.3 kb | Distal (>10kb) Multiome | 446 | |
| chr11:126,355,100–126,356,405 | 51.6 kb | Distal (>10kb) Multiome | 596 | |
| chr11:126,440,475–126,441,596 | 136.9 kb | Distal (>10kb) Multiome | 367 | |
| chr11:126,480,538–126,481,044 | 176.8 kb | Distal (>10kb) Multiome HiCAR | 487 | |
| chr11:126,497,641–126,499,015 | 194.4 kb | Distal (>10kb) Multiome | 250 | |
| chr11:126,502,215–126,503,760 | 199.1 kb | Distal (>10kb) Multiome | 129 |
Genomic view of the DCPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.