Enables nuclear estrogen receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including decidualization; epigenetic programming in the zygotic pronuclei; and spindle assembly involved in female meiosis. Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCAF13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:103,140,428–103,141,578 | 274.5 kb | Distal (>10kb) Multiome | 259 | |
| chr8:103,298,291–103,299,527 | 116.4 kb | Distal (>10kb) Multiome | 649 | |
| chr8:103,370,990–103,372,400 | 43.9 kb | Distal (>10kb) Multiome | 619 | |
| chr8:103,411,179–103,411,836 | 3.5 kb | Proximal (<10kb) | 165 | |
| chr8:103,413,054–103,413,358 | 2.0 kb | Proximal (<10kb) | 23 | |
| chr8:103,414,336–103,415,724 | 170 bp | At TSS Multiome | 1010 | |
| chr8:103,498,473–103,502,003 | 86.3 kb | Distal (>10kb) Multiome | 670 | |
| chr8:103,623,788–103,624,534 | 208.8 kb | Distal (>10kb) Multiome | 178 | |
| chr8:103,650,732–103,651,447 | 235.8 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the DCAF13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.