This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for DCAF12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,048,315–34,049,845 | 77.5 kb | Distal (>10kb) Multiome | 1045 | |
| chr9:34,049,943–34,050,924 | 76.2 kb | Distal (>10kb) Multiome | 283 | |
| chr9:34,126,146–34,127,302 | 22 bp | At TSS Multiome | 826 | |
| chr9:34,178,460–34,179,845 | 52.4 kb | Distal (>10kb) Multiome | 814 | |
| chr9:34,328,711–34,329,961 | 202.7 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,363,597–34,364,212 | 237.2 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 248.5 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 250.3 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 254.2 kb | Distal (>10kb) Multiome | 763 |
Genomic view of the DCAF12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.