This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for DCAF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,567,065–23,567,976 | 547.1 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr14:23,910,478–23,911,853 | 204.0 kb | Distal (>10kb) Multiome | 310 | |
| chr14:23,953,479–23,954,293 | 161.0 kb | Distal (>10kb) Multiome | 897 | |
| chr14:23,988,469–23,989,172 | 126.0 kb | Distal (>10kb) Multiome | 439 | |
| chr14:24,036,218–24,036,993 | 78.2 kb | Distal (>10kb) Multiome | 627 | |
| chr14:24,051,239–24,052,875 | 62.8 kb | Distal (>10kb) Multiome HiCAR | 821 | |
| chr14:24,080,914–24,082,038 | 33.3 kb | Distal (>10kb) Multiome | 706 | |
| chr14:24,093,491–24,095,115 | 20.6 kb | Distal (>10kb) Multiome | 990 | |
| chr14:24,108,868–24,109,078 | 5.7 kb | Proximal (<10kb) | 542 | |
| chr14:24,113,681–24,115,917 | 184 bp | At TSS Multiome | 1166 | |
| chr14:24,135,549–24,136,884 | 21.3 kb | Distal (>10kb) Multiome | 778 | |
| chr14:24,140,526–24,142,331 | 26.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr14:24,146,204–24,148,108 | 32.0 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 46.5 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 57.1 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 74.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 80.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 98.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 101.2 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 117.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 127.8 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 156.7 kb | Distal (>10kb) Multiome | 1089 | |
| chr14:24,299,120–24,300,273 | 185.0 kb | Distal (>10kb) Multiome | 892 | |
| chr14:24,315,948–24,316,753 | 201.6 kb | Distal (>10kb) Multiome | 736 | |
| chr14:24,332,251–24,333,127 | 217.7 kb | Distal (>10kb) Multiome | 740 | |
| chr14:24,365,652–24,366,243 | 251.0 kb | Distal (>10kb) Multiome | 668 | |
| chr14:24,366,594–24,369,358 | 252.4 kb | Distal (>10kb) Multiome | 921 | |
| chr14:24,388,547–24,389,510 | 274.2 kb | Distal (>10kb) Multiome | 161 | |
| chr14:24,398,424–24,399,423 | 284.2 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the DCAF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.