This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for DAZAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAZAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAZAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,025,646–51,026,823 | 212.4 kb | Distal (>10kb) Multiome | 1016 | |
| chr12:51,047,625–51,048,573 | 190.7 kb | Distal (>10kb) Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 155.2 kb | Distal (>10kb) Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 65.8 kb | Distal (>10kb) Multiome | 853 | |
| chr12:51,217,044–51,218,599 | 20.7 kb | Distal (>10kb) Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 137 bp | At TSS Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 31.2 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 82.1 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 132.8 kb | Distal (>10kb) Multiome | 431 | |
| chr12:51,390,937–51,392,088 | 152.7 kb | Distal (>10kb) Multiome | 504 | |
| chr12:51,395,449–51,396,000 | 156.9 kb | Distal (>10kb) Multiome | 274 | |
| chr12:51,424,595–51,425,524 | 186.1 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the DAZAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.