This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for DAP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:10,484,832–10,486,353 | 275.8 kb | Distal (>10kb) Multiome | 499 | |
| chr5:10,514,072–10,514,528 | 247.0 kb | Distal (>10kb) Multiome | 182 | |
| chr5:10,533,291–10,533,909 | 227.8 kb | Distal (>10kb) Multiome | 83 | |
| chr5:10,562,689–10,565,568 | 197.0 kb | Distal (>10kb) Multiome | 622 | |
| chr5:10,627,273–10,628,369 | 133.3 kb | Distal (>10kb) Multiome | 678 | |
| chr5:10,637,215–10,638,114 | 123.6 kb | Distal (>10kb) Multiome | 155 | |
| chr5:10,760,191–10,760,412 | 821 bp | At TSS | 353 | |
| chr5:10,760,531–10,762,133 | 90 bp | At TSS Multiome | 768 |
Genomic view of the DAP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.