Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; inner medullary collecting duct development; and negative regulation of nodal signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DACT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DACT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DACT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:168,123,195–168,123,950 | 196.1 kb | Distal (>10kb) Multiome | 56 | |
| chr6:168,125,394–168,126,053 | 194.0 kb | Distal (>10kb) Multiome | 50 | |
| chr6:168,208,665–168,209,782 | 110.5 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr6:168,273,004–168,273,605 | 46.6 kb | Distal (>10kb) Multiome | 82 | |
| chr6:168,273,729–168,274,619 | 45.5 kb | Distal (>10kb) Multiome | 376 | |
| chr6:168,301,153–168,302,449 | 17.9 kb | Distal (>10kb) Multiome | 501 | |
| chr6:168,315,620–168,315,910 | 3.9 kb | Proximal (<10kb) | 21 | |
| chr6:168,318,096–168,318,484 | 1.3 kb | Proximal (<10kb) | 211 | |
| chr6:168,318,677–168,318,827 | 949 bp | At TSS | 13 | |
| chr6:168,318,963–168,320,277 | 135 bp | At TSS Multiome | 217 | |
| chr6:168,328,567–168,328,831 | 8.8 kb | Proximal (<10kb) | 9 | |
| chr6:168,331,858–168,332,423 | 12.5 kb | Distal (>10kb) Multiome | 163 | |
| chr6:168,355,797–168,356,392 | 36.4 kb | Distal (>10kb) Multiome | 356 | |
| chr6:168,363,706–168,364,464 | 44.5 kb | Distal (>10kb) Multiome | 99 | |
| chr6:168,370,305–168,370,753 | 50.8 kb | Distal (>10kb) Multiome | 363 | |
| chr6:168,440,551–168,442,035 | 121.5 kb | Distal (>10kb) Multiome | 238 |
Genomic view of the DACT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.