This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYTH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYTH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYTH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,008,669–6,009,907 | 263.4 kb | Distal (>10kb) Multiome | 1068 | |
| chr7:6,058,614–6,059,749 | 213.5 kb | Distal (>10kb) Multiome | 916 | |
| chr7:6,081,109–6,081,851 | 191.1 kb | Distal (>10kb) Multiome | 904 | |
| chr7:6,103,982–6,105,662 | 167.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr7:6,271,933–6,273,059 | 28 bp | At TSS Multiome | 582 | |
| chr7:6,348,284–6,349,527 | 76.3 kb | Distal (>10kb) Multiome | 787 | |
| chr7:6,374,107–6,375,074 | 101.8 kb | Distal (>10kb) Multiome | 778 | |
| chr7:6,447,046–6,448,661 | 175.3 kb | Distal (>10kb) Multiome | 944 | |
| chr7:6,483,337–6,484,560 | 211.6 kb | Distal (>10kb) Multiome | 748 | |
| chr7:6,502,814–6,505,187 | 231.5 kb | Distal (>10kb) Multiome | 573 | |
| chr7:6,516,399–6,516,954 | 243.9 kb | Distal (>10kb) Multiome | 245 | |
| chr7:6,526,260–6,527,132 | 254.0 kb | Distal (>10kb) Multiome | 313 | |
| chr7:6,530,620–6,531,774 | 258.6 kb | Distal (>10kb) Multiome | 296 | |
| chr7:6,536,237–6,537,265 | 264.3 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the CYTH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.