The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for CYTH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYTH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYTH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,723,107–78,723,697 | 58.8 kb | Distal (>10kb) Multiome | 236 | |
| chr17:78,781,367–78,783,044 | 140 bp | At TSS Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 58.6 kb | Distal (>10kb) Multiome | 1124 | |
| chr17:78,924,768–78,925,859 | 143.1 kb | Distal (>10kb) Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 189.3 kb | Distal (>10kb) Multiome | 359 | |
| chr17:79,009,356–79,010,250 | 227.5 kb | Distal (>10kb) Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 242.1 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 292.5 kb | Distal (>10kb) Multiome | 657 |
Genomic view of the CYTH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.