Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CYRIB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYRIB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYRIB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:129,821,405–129,822,168 | 194.9 kb | Distal (>10kb) Multiome | 108 | |
| chr8:129,832,812–129,833,944 | 183.2 kb | Distal (>10kb) Multiome HiCAR | 175 | |
| chr8:129,843,045–129,843,736 | 173.3 kb | Distal (>10kb) Multiome | 117 | |
| chr8:129,939,023–129,940,545 | 76.8 kb | Distal (>10kb) Multiome | 936 | |
| chr8:129,983,581–129,984,611 | 32.7 kb | Distal (>10kb) Multiome | 450 | |
| chr8:130,015,243–130,017,286 | 222 bp | At TSS Multiome | 745 | |
| chr8:130,019,968–130,020,440 | 3.3 kb | Proximal (<10kb) | 59 | |
| chr8:130,203,971–130,204,947 | 187.8 kb | Distal (>10kb) Multiome | 170 |
Genomic view of the CYRIB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.