Predicted to enable molecular adaptor activity. Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYREN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYREN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYREN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:134,890,877–134,892,305 | 279.2 kb | Distal (>10kb) Multiome | 673 | |
| chr7:134,986,110–134,987,248 | 184.1 kb | Distal (>10kb) Multiome | 1029 | |
| chr7:135,169,120–135,169,791 | 732 bp | At TSS | 443 | |
| chr7:135,170,026–135,171,132 | 13 bp | At TSS Multiome | 1132 | |
| chr7:135,210,700–135,212,153 | 40.9 kb | Distal (>10kb) Multiome | 729 | |
| chr7:135,335,404–135,336,080 | 165.2 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the CYREN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.