This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for CYGB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYGB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYGB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:76,240,278–76,241,169 | 297.0 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 272.6 kb | Distal (>10kb) Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 183.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 153.2 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 151.7 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 84.5 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 36.3 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 31.2 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 88 bp | At TSS Multiome | 192 | |
| chr17:76,540,451–76,541,323 | 3.3 kb | Proximal (<10kb) Multiome | 478 | |
| chr17:76,547,428–76,547,595 | 9.7 kb | Proximal (<10kb) | 360 | |
| chr17:76,557,376–76,557,942 | 20.0 kb | Distal (>10kb) Multiome | 906 | |
| chr17:76,585,404–76,586,417 | 48.2 kb | Distal (>10kb) Multiome | 591 | |
| chr17:76,612,985–76,613,550 | 75.6 kb | Distal (>10kb) Multiome | 308 | |
| chr17:76,671,049–76,672,200 | 134.0 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr17:76,708,018–76,708,518 | 170.5 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,710,928–76,711,574 | 173.4 kb | Distal (>10kb) Multiome | 421 | |
| chr17:76,725,921–76,727,506 | 189.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr17:76,735,995–76,738,370 | 198.6 kb | Distal (>10kb) Multiome | 1227 |
Genomic view of the CYGB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.