CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
Transcription factors with Perturb-seq knockdown data for CUL4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUL4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUL4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:112,942,743–112,944,278 | 266.7 kb | Distal (>10kb) Multiome | 632 | |
| chr13:112,968,613–112,969,532 | 240.4 kb | Distal (>10kb) Multiome | 497 | |
| chr13:113,022,696–113,023,521 | 186.5 kb | Distal (>10kb) Multiome HiCAR | 461 | |
| chr13:113,152,885–113,154,060 | 56.3 kb | Distal (>10kb) Multiome | 714 | |
| chr13:113,179,328–113,180,131 | 30.0 kb | Distal (>10kb) Multiome | 164 | |
| chr13:113,208,078–113,210,214 | 721 bp | At TSS Multiome | 1103 | |
| chr13:113,296,598–113,297,816 | 87.6 kb | Distal (>10kb) Multiome | 1104 | |
| chr13:113,393,735–113,394,451 | 184.5 kb | Distal (>10kb) Multiome | 576 | |
| chr13:113,397,604–113,398,329 | 188.3 kb | Distal (>10kb) Multiome | 76 | |
| chr13:113,489,310–113,491,886 | 281.3 kb | Distal (>10kb) Multiome | 791 |
Genomic view of the CUL4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.