This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CTTNBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTTNBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTTNBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:117,810,393–117,811,576 | 62.4 kb | Distal (>10kb) Multiome | 205 | |
| chr7:117,871,807–117,874,215 | 113 bp | At TSS Multiome | 574 | |
| chr7:117,875,572–117,876,104 | 3.4 kb | Proximal (<10kb) | 102 | |
| chr7:117,993,107–117,994,287 | 120.3 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the CTTNBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.