Transcription factors with Perturb-seq knockdown data for CTTN-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTTN-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTTN-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:70,141,113–70,142,538 | 256.7 kb | Distal (>10kb) Multiome | 319 | |
| chr11:70,202,749–70,203,803 | 195.2 kb | Distal (>10kb) Multiome | 782 | |
| chr11:70,213,835–70,214,626 | 184.2 kb | Distal (>10kb) Multiome | 51 | |
| chr11:70,219,601–70,220,630 | 178.3 kb | Distal (>10kb) Multiome | 148 | |
| chr11:70,269,844–70,271,534 | 127.9 kb | Distal (>10kb) Multiome | 790 | |
| chr11:70,397,703–70,399,001 | 22 bp | At TSS Multiome | 843 |
Genomic view of the CTTN-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.