This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for CTNNA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTNNA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTNNA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:67,386,856–67,387,878 | at TSS | At TSS | 157 | |
| chr10:67,763,355–67,765,388 | 376.9 kb | Distal (>10kb) Multiome | 1018 | |
| chr10:67,765,907–67,766,103 | 2.3 kb | Proximal (<10kb) | 17 | |
| chr10:67,788,290–67,788,969 | 401.1 kb | Distal (>10kb) Multiome | 406 | |
| chr10:67,849,336–67,850,018 | 462.1 kb | Distal (>10kb) Multiome | 751 | |
| chr10:67,861,706–67,862,739 | 474.6 kb | Distal (>10kb) Multiome | 215 | |
| chr10:67,884,003–67,885,448 | 497.2 kb | Distal (>10kb) Multiome | 1061 |
Genomic view of the CTNNA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.