The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CSTF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSTF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSTF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:32,891,344–32,894,653 | 268.5 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:33,015,524–33,016,542 | 145.5 kb | Distal (>10kb) Multiome | 837 | |
| chr11:33,038,936–33,040,258 | 122.0 kb | Distal (>10kb) Multiome | 917 | |
| chr11:33,040,776–33,041,667 | 120.1 kb | Distal (>10kb) Multiome | 161 | |
| chr11:33,049,426–33,050,404 | 111.5 kb | Distal (>10kb) Multiome | 103 | |
| chr11:33,159,614–33,159,870 | 1.6 kb | Proximal (<10kb) | 92 | |
| chr11:33,160,986–33,162,028 | 129 bp | At TSS Multiome | 908 | |
| chr11:33,256,736–33,259,047 | 97.1 kb | Distal (>10kb) Multiome | 993 | |
| chr11:33,375,703–33,377,039 | 214.9 kb | Distal (>10kb) Multiome | 329 |
Genomic view of the CSTF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.