This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CSTF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSTF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSTF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:54,843,792–54,844,536 | 1548.2 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr20:54,849,030–54,850,253 | 1542.6 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:55,028,728–55,030,077 | 1362.9 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:56,358,373–56,359,678 | 33.5 kb | Distal (>10kb) Multiome | 612 | |
| chr20:56,391,539–56,393,046 | 52 bp | At TSS Multiome | 1080 | |
| chr20:56,400,135–56,400,293 | 7.8 kb | Proximal (<10kb) | 148 | |
| chr20:56,468,222–56,468,931 | 76.2 kb | Distal (>10kb) Multiome | 887 | |
| chr20:56,624,898–56,625,604 | 232.7 kb | Distal (>10kb) Multiome | 210 | |
| chr20:56,628,380–56,631,136 | 238.0 kb | Distal (>10kb) Multiome | 551 | |
| chr20:56,690,044–56,691,001 | 298.2 kb | Distal (>10kb) Multiome | 191 | |
| chr20:57,002,615–57,003,823 | 610.9 kb | Distal (>10kb) Multiome HiCAR | 200 |
Genomic view of the CSTF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.